WWE protein domain
Umsebenzi
[hlela | Hlela umthombo]Izizinda ze-WWE zenzeka ngezigaba ezimbili ezisebenzayo zamaprotheni, okungukuthi lezo ezihambisana nobiquitination kanye nalezo ezihlobene ne-poly-ADP ribosylation ( PARP ).Ngakho-ke, izizinda ze- WWE zibamba umsebenzi obalulekile ekudlulisweni kwesiginali, ukonakala kwamaprotheni, ukulungiswa kwe-DNA kanye ne- apoptosis . [1]
Ukusebenzisana kwamaprotheni
[hlela | Hlela umthombo]I WWE lesizinda yaqanjwa ezintathu zalo alondolozwe izinsalela, W no-E izinsalela ( tryptophans futhi glutamate ngokulandelana), futhi kubikezelwa ukuthi ethize ngasolinye amaprotheni-amaprotheni ekusebenzisaneni e ubiquitin futhi Adp ribose lokuhlanganisa izinhlelo (midi Adp ribose polymerase).Lesi sizinda itholakala njengendlela Ngohlelo uphinda ngesikhathi N-ukuphela Deltex, a cytosolic effector ka Notch mkhosi okucatshangwa uxhumano nomsebenzisi N-ukuphela kwe-Notch yokwamukela . [2] Iphinde itholakale njengemodyuli yokuxhumana kuma- protein ubiquination kanye ne-ADP ribosylation protein . [1]
Isakhiwo
[hlela | Hlela umthombo]Ngaphakathi kwemodyuli ngayinye ye-WWE, izinsalela zakha izakhiwo ezimbili ezifanayo ezibalulekile ekusimeni kwaso.Amamojula amabili e-WWE ahlangana futhi akha umsantsa omkhulu ofanele ukubopha ama-polypeptides anwetshiwe.Amamojula amabili e-WWE amukela ukwakheka okuhlanganisiwe ikakhulu okuqukethe imicu ye-beta, nge- alpha helix eyodwa kumamojula womabili nangengxenye eyengeziwe emfushane ye-helical kusigaba sesibili seWWE.Amamojula amabili we-WWE abamba i- eksisi yokujikeleza kabili. [2]
Izinkomba
[hlela | Hlela umthombo]- ↑ 1.0 1.1 The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation.. Cite error: Invalid
<ref>tag; name "pmid11343911" defined multiple times with different content - ↑ 2.0 2.1 Structure and Notch receptor binding of the tandem WWE domain of Deltex. Cite error: Invalid
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